|
KMID : 1037020180070010013
|
|
Medical Lasers; Engineering, Basic Research, and Clinical Application
2018 Volume.7 No. 1 p.13 ~ p.20
|
|
|
Pneumatic Injection Therapy-Induced Transcutaneous Penetration of Hypertonic Glucose Solution: Macro- and Microscopic Analyses of Human and Rat Tissues
|
|
Kim Hyun-Jo
Han Seung-Ho
Park A-Young
Kim Hee-Su
Hong Gi-Woong
Lim Ee-Seok
Cho Sung-Bin
|
|
|
Abstract
|
|
|
Background and Objectives: Pneumatic injection therapy (PIT) is a needle-free, penetration-enhanced, transdermal method of delivering drugs into the skin. This study evaluated topographically the PIT-induced transcutaneous infiltration of a 20% hypertonic glucose solution in fresh human cadavers and outlined the microscopic patterns and reactions to PIT with a 20% glucose solution in in vivo rat skin.
Materials and Methods: The penetration depths of a 20% glucose solution by PIT were analyzed macroscopically in 10 hemifaces from fresh cadavers. In addition, the infiltration patterns of PIT with a 20% glucose solution performed in vivo in rats were analyzed through a histology evaluation.
Results: Pneumatic injections of a hypertonic glucose solution generated PIT zones in the subcutaneous fat and superficial temporal fascia layers (10 out of 10 hemifaces), superficial layer of the deep temporal fascia (DTF; 8 out of 10 hemifaces), and deep layer of the DTF (7 out of 10 hemifaces). In addition, distinctive PIT zones were generated in rat tissues from the upper papillary deep to the muscle and fascia layers.
Conclusion: The data suggest that PIT-induced, jet infiltration of a 20% hypertonic glucose solution contributes to clinical improvement of skin laxity by stimulating the wound repair processes and increasing collagen production throughout multiple layers of the skin.
|
|
|
KEYWORD
|
|
|
Transcutaneous pneumatic injection, Prolotherapy, Hyperglycemic solution, Cadaver, Rat, Ultrasound
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|